GCSE Biology (Combined) Edexcel

This subject is broken down into 53 topics in 11 modules:

  1. Key Concepts 7 topics
  2. Cells and Control 5 topics
  3. Genetics 5 topics
  4. Natural Selection 4 topics
  5. Genetic Modification 2 topics
  6. Health, Disease and Development of Medicine 8 topics
  7. Plant Structures 3 topics
  8. Animal Biology 6 topics
  9. Exchange and Transport- Animals 6 topics
  10. Ecosystems 4 topics
  11. Material Cycles 3 topics
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  • 11
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  • 53
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  • 17,911
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  • 2+
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This page was last modified on 28 September 2024.

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Biology (Combined)

Key Concepts

Key Concepts: Cells

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Key Concepts: Cells

  • The basic unit of all organisms, from bacteria to plants and humans, is the cell.
  • There are two main types of cells: prokaryotic (typically bacteria) and eukaryotic (found in plants and animals).
  • Prokaryotic cells are smaller and simpler, lacking a nucleus and most other organelles. Instead, their genetic material is in the cytoplasm.
  • Eukaryotic cells, on the other hand, have a nucleus that houses the cell's DNA. They also contain specialised organelles, each with a specific function.
  • Key organelles to understand are the nucleus (controls the cell's activities), mitochondria (where most energy is released in respiration), cytoplasm (where most of the cell's activities take place), cell membrane (controls what goes in and out of the cell), ribosomes (where proteins are made) and, in plant cells, chloroplasts (where photosynthesis happens) and a cell wall (made of cellulose, gives structure and support).
  • Different types of cells have different forms, relating to their function. For example, nerve cells are long to carry signals over long distances, while root hair cells in plants are thin and elongated for maximum absorption of water and minerals.
  • Cells divide in a process called cell division. In body cells this is mitosis, creating two identical daughter cells for growth and repair. In sex cells this is meiosis, creating four non-identical daughter cells for sexual reproduction.
  • The cycle of cell growth and division is controlled by the cell cycle. Any errors in this process can lead to uncontrollable growth or cancer.
  • Substances move in and out of cells via diffusion, osmosis, and active transport. Each of these processes involve different mechanisms and energy requirements.
  • Photosynthesis, the process where green plants and algae convert carbon dioxide and water into glucose and oxygen using light energy, happens within chloroplasts.
  • The rate of photosynthesis can be affected by light intensity, carbon dioxide concentration, and temperature.
  • Respiration, where energy is released from the breakdown of glucose, happens within cells. It can be either aerobic (with oxygen) or anaerobic (without oxygen, also known as fermentation). Both forms of respiration have real-world applications and implications, for example in yeast fermentation for bread and beer production.

Course material for Biology (Combined), module Key Concepts, topic Key Concepts: Cells

Biology (Combined)

Health, Disease and Development of Medicine

Antibiotics and Other Medicines

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Antibiotics and Other Medicines

  • Antibiotics are medicines that help in the treatment of bacterial infections. They work by either killing the bacteria or preventing them from reproducing and spreading.

  • Antibiotics are ineffective against viral infections. This is because viruses do not have cellular structures such as cell walls which antibiotics typically target.

  • Over-prescription and misuse of antibiotics can lead to antibiotic resistance. This is a major concern, as bacteria can evolve, due to natural selection, to become resistant to these drugs.

  • Antibiotic resistance can spread between different strains of bacteria. This can make previously treatable bacterial infections more dangerous and difficult to control.

  • Penicillin, discovered by Alexander Fleming, was the first widely used antibiotic. It was discovered accidentally when Fleming noticed a mould (Penicillium notatum) was effective in killing bacteria.

  • There are different types of medicines aside from antibiotics. Painkillers, for example, do not tackle the cause of disease but help reduce symptoms such as pain and fever. This can make individuals feel better and possibly help the immune system fight off the infection.

  • Other medicines, like antivirals and antifungals, are used to combat viral and fungal infections respectively.

  • Miller and Urey's experiment showed how simple organic molecules, like amino acids, could have first been made on the early Earth. While the exact conditions of early Earth may have been different than the conditions in the Miller-Urey experiment, it highlighted the possibility of life originating from simple chemical processes.

  • The development, testing, and regulations around new medicines are strict to ensure safety. Stages include preclinical testing on cells and animals, followed by clinical trials on human volunteers. These stages assess the effectiveness and examine side effects. It can take many years for a new drug to pass through these checks and safety measures.

  • Vaccinations are an important way of controlling infectious diseases within a population. They train the immune system to attack certain diseases by injecting a harmless version of the pathogen. This leads to immunity without suffering the symptoms of the disease.

  • Herd immunity occurs when a large percentage of the population is vaccinated, reducing the probability of a pathogen infecting and spreading through the population. This can protect individuals who can't receive vaccinations due to health reasons.

  • Hygiene practises such as washing hands regularly and sterilising medical equipment also play a significant role in preventing the spread of infections.

  • Lifestyle factors can also contribute to disease. Poor diet, lack of exercise, alcohol misuse, and smoking can lead to health conditions such as heart disease, stroke, type II diabetes and lung cancer.

Course material for Biology (Combined), module Health, Disease and Development of Medicine, topic Antibiotics and Other Medicines

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